245 DISPOSITION OF INDOMETHACIN IN PREMATURE INFANTS
نویسندگان
چکیده
منابع مشابه
Indomethacin treatment in small versus large premature infants with ductus arteriosus. Comparison of plasma indomethacin concentration and clinical response.
An analysis of clinical response and plasma indomethacin concentration was performed on 10 small (less than or equal to 1000 g) and 12 large (greater than 1000 g) premature infants who had symptomatic ductus arteriosus and required intravenous indomethacin therapy (0.3 mg/kg per day). The postnatal age, daily fluid intake, and cardiopulmonary status of the two groups at time of study were compa...
متن کاملA preliminary study on pharmacokinetics of oral indomethacin in premature infants in north India.
BACKGROUND & OBJECTIVES Patent ductus arteriosus (PDA) is a frequent complication in premature infants. Intravenous indomethacin is the standard mode of medical therapy and has been shown to be efficacious in closing the ductus. In our setup, oral indomethacin is being regularly used for medical treatment of suspected or clinically diagnosed PDA. Non-availability of the parenteral preparation a...
متن کاملEchocardiographic flow pattern of patent ductus arteriosus: a guide to indomethacin treatment in premature infants.
AIM To compare the efficacy and safety of an indomethacin treatment strategy based on serial echocardiographic measurement of patent ductus arteriosus (PDA) flow pattern with a standard protocol. METHODS Neonates weighing less than 1500 g at birth, who required respiratory support, and who had developed symptomatic PDA, were studied. PDA was confirmed in all infants using colour Doppler echoc...
متن کاملRenal follow up of premature infants with and without perinatal indomethacin exposure.
AIMS To evaluate early childhood renal growth, structure, and function in children born at less than 33 weeks gestation and to investigate possible independent effects of perinatal indomethacin exposure. METHODS A total of 66 children born at less than 33 weeks gestation, 31 of them with perinatal indomethacin exposure (study group) and 35 without (control group), were examined at 2-4 years o...
متن کاملTolerance of intravenous indomethacin treatment for premature infants with patent ductus arteriosus.
stable or partial response, suggesting that, in addition to causing sclerosis of bone, APD may have an antitumour effect. Factors released from tumours stimulate osteoblastic activity3 and osteolysis mediated by osteoclasts.4 APD is a potent inhibitor of osteoclast function, and such inhibition combined with the osteoblastic factors produced by tumour cells may explain the bony sclerosis seen i...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1978
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-197804001-00250